Research Grant

– 김병수 교수 -1 면역조절 줄기세포의 배양액 첨가물질 개발을 통한 면역조절능 특화 세포 치료제 개발 /60,000,000

– 김병수 교수 – 혈액질환 환자에서 발생한 호중구 감소성 발열의 위험성 분류 체계에 대한 검증 및 MASCC 위험 모델과의 비교연구/10,000,000

– 김병수 교수 – 텔로머라제 억제 siRNA를 이용한 항암 표적치료기술의 개발/20,000,000

– 인간 역분화 줄기세포의 완전한 무지지세포 배양을 위한 표준화 인간세포 유래 조건화 배지 생산 및 기전 규명.

(연구재단, 2012-2017) 총 5억원

– 중간엽 줄기세포의 배양액 첨가물질 개발을 통한 면역조절능 특화 세포치료제 개발 세부과제.

(산업자원부, 2014-2015) 총 1억2천만원

– 새로운 세포 견인력 측정장치를 이용한 morphogen농도 구배상의 세포 군집이동 기전 규명.

(연구재단, 2014–2016) 총 3억원

– 턱뼈 결손부 재건 위한 바이오 프린팅 잉크용 스마트 수화젤의 개발 및 적용.

(한국보건산업진흥원, 2014-2017) 총 6억원

– 임신성 고혈압의 병태생리 규명 및 치료제로서의 pravastatin의 효용성에 관한 연구.

(연구재단, 2012-2015) 총 1억5천만원

다중스케일 조립기술 기반 기능성 심장 조직 제작 및 독성 유효성 평가

(한국연구재단 : 2016.11.29-2021.08.28) 1억 1천만원

Publication

2020

Hae Min Yang, Jie Ying Teoh, Guk Hee Yim, Yongdoo Park, Young Gyu Kim, Jongseong Kim*, Dongwon Yoo* “Label-Free Analysis of Multivalent Protein Binding using Bioresponsive Nanogels and Surface Plasmon Resonance (SPR)” ACS Applied Materials & Interfaces, 2020, doi.org/10.1021/acsami.9b17328

Yongjun Jang, Seung-Cheol Choi, Do-Sun Lim, Jong-Hoon Kim, Jongseong Ki *, and Yongdoo Park*, “Modulating cardiomyocyte and fibroblast interaction using layer-by-layer deposition facilitates synchronisation of cardiac macro tissues” Soft Matter, 2020, 2

2019

Jiwon Kim, Su-kyoung Lee, Dawid Schellingerhout, Matthias Nahrendorf, Kwangmeyung Kim, Jongseong Kim*, Dong-Eog Kim*, “Spectroscopic Assessment of Gold Nanoparticle Biodistribution using Surface Plasmon Resonance Phenomena”ACS Biomaterials Science & Engineering, 12

Hwanseok Jang, Jongseong Kim, Jennifer H Shin, Jeffrey J Fredberg, Chan Young Park*, Yongdoo Park*, “Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration” 2019, 152

Sam G Edalat, Yongjun Jang, Jongseong Kim*, and Yongdoo Park*, “Collagen Type I Containing Hybrid Hydrogel Enhances Cardiomyocyte Maturation in a 3D Cardiac Model” POLYMERS, 2019;11.

Hwanseok Jang‡, Jongseong Kim‡, Jennifer H Shin, Jeffrey J Fredberg, Chan Young Park*, Yongdoo Park*, “Traction microscopy with integrated microfluidics: responses of the multi-cellular island to gradients of HGF” LAB ON A CHIP, 2019;19.

2018

Lee KG, Lee KS, Kang YJ, Hwang JH, Lee SH,Park SH, Park Y, Cho YS, Lee BK.”Rabbit Calvarial Defect Model for Customized 3D-Printed Bone Grafts” TISSUE ENGINEERING PART C-METHODS, 2018 May;24.

Yong Guk Kang,Hwanseok Jang,Taeseok Daniel Yang, Jacob Notbohm, Youngwoon Choi, Yongdoo Park,* and Beop-Min Kima,* “Quantification of focal adhesion dynamics of cell movement based on cell-induced collagen matrix deformation using second-harmonic generation microscopy” JOURNAL OF BIOMEDICAL OPTICS, 2018;23.

Jaeyeon Lee, Se-Hwan Lee, Bu-Kyu Lee, Sang-Hyug Park,Young-Sam Cho, and Yongdoo Park* “Fabrication of Microchannels and Evaluation of Guided Vascularization in Biomimetic Hydrogels” TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018;15.

Jaeyeon Lee, Myeongjin Song, Jongseong Kim*, and Yongdoo Park*, “Comparison of Angiogenic Activities of Three Neuropeptides, Substance P, Secretoneurin, and Neuropeptide Y Using Myocardial Infarction” TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018;15.

Jaeyeon Lee, Se-Hwan Lee, Byung Soo Kim, Young-Sam Cho, and Yongdoo Park*, “Development and Evaluation of Hyaluronic Acid-Based Hybrid Bio-Ink for Tissue Regeneration” TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018;15.

Su-kyung lee, Yongdoo park, and Jongseong Kim*, “Thermoresponsive behavior of magnetic nanoparticle complexed pNIPAM-co-AAc microgels” APPLIED SCIENCES, 2018;8.

2017

Jang H, Notbohm J, Gweon B, Cho Y, Park CY, Kee SH, Fredberg JJ, Shin JH, Park Y. “Homogenizing cellular tension by hepatocyte growth factor in expanding epithelial monolayer” Scientific Reports, 2017 April;8.

Siwan Park, Hwanseok Jang, Byung Soo Kim, Changmo Hwang, Gi Seok Jeong*, and Yongdoo Park*, Directional Migration of Mesenchymal Stem Cells under an SDF-1α Gradient on a Microfluidic Device, PLOS ONE, 2017

2016

Hong S, Lee JY, Hwang C, Shin JH, Park Y. “Inhibition of Rho-Associated Protein Kinase Increases the Angiogenic Potential of Mesenchymal Stem Cell Aggregates via Paracrine Effects” Tissue Eng Part A. 2016 Feb;22(3-4):233-43.

Pan H, Han JJ, Park YD, Cho TH, Hwang SJ. “Effect of sustained release of rhBMP-2 from dried and wet hyaluronic acid hydrogel carriers compared with direct dip coating of rhBMP-2 on peri-implant osteogenesis of dental implants in canine mandibles” J Craniomaxillofac Surg. 2016 Feb;44(2):116-25

Kim SK, Cho YH, Han JJ, Kim IS, Park YD, Hwang SJ, “Comparative Study of BMP-2 Alone and Combined with VEGF Carried by Hydrogel for Maxillary Alveolar Bone Regeneration” TERM. 2016 Apr;13(2):171-181

Notbohm J, Banerjee S, Utuje KJ, Gweon B, Jang H, Park Y, Shin J, Butler JP, Fredberg JJ, Marchetti MC.”Cellular Contraction and Polarization Drive Collective Cellular Motion”Biophys J. 2016 Jun 21;110(12):2729-38

Kim JH, Park Y, Jung Y, Kim SH, Kim SH,”Combinatorial therapy with three-dimensionally cultured adipose-derived stromal cells and self-assembling peptides to enhance angiogenesis and preserve cardiac function in infarcted hearts” J Tissue Eng Regen Med. 2016 Jun 3.

Kim SK, Lee JY, Song MJ, Kim MR, Hwang SJ, Jang HS, Park YD.”Combination of three angiogenic growth factors has synergistic effects on sprouting of endothelial cell/mesenchymal stem cell-based spheroids in a 3D matrix.” J Biomed Mater Res B Appl Biomater. 2016 Nov;104(8):1535-1543

2015

Jin IG, Kin JH, Wu HG, Kim SK, Park YD, Hwang SJ “Effect of bone marrow-derived stem cells and bone morphogenetic protein-2 on treatment of osteoradionecrosis in a rat model” J Craniomaxillofac Surg, 2015, Ocr;43(8):1478-86

 

2014

Myeongjin Song, Yongdoo Park, Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1, and angiogenic peptide Ac-SDKP, Biomaterials, 2014, 35, 2436-2445

Sookkyung Kim, Huinam Park, Yongdoo Park, Synergistic restoring effects of isoproterenol and magnesium on KCNQ1- inhibited bradycardia cell models cultured in microelectrode array, Cardiology, 2014, 128, 15-24

So Jeong Yoon, Soyoung Hong, et al., Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel, J of Bioscience and Bioengineering, 2014, in press.

Kwangho Lee, Yongdoo Park, Sanghoon Lee, Integration of microfluidic chip with biomimetic hydrogel for 3D controlling and monitoring of cell alignment and migration, J of Biomed Mater Res A, 2014, 102, 1164-1172

Yoon Jeong Choi, Ho Sung Son, Kook Hee Son, Yongdoo Park, Insup Noh, Tissue regeneration in the pores of poly (lactide-co-glycolide)-impregnated wall of expanded ePTFE hybrid graft, Tissue Engineering, and Regenerative Medicine, 2014, 11, 1-10

2013

Hong SY, Song SJ, Lee JY, Jang HS, choi JS, Sun k, Park YD. “Cellular behavior in micropatterned hydrogels by bioprinting system depended on the cell types and cellular interaction” Journal of Bioscience and Bioengineering, 2013, 116(2): 224-230

Kim JH, Park IS, Park Y, Jung Y, Kim SH, Kim SH. “Therapeutic angiogenesis of three-dimensionally cultured adipose-derived stem cells in rat infarcted hearts” Cytotherapy, 2013, 15(5):542-556

LEE JY, LEE KB, Sun K, Park YD. “Morphological Changes of Human Mesenchymal Stem Cells on a Large Area of Nanopatterned Surface” Biomaterials Research, , 2013, 17(1) : 1-6

2012

Choi YJ, Jeon SK, Kim J, Park Y, Yoon SZ, Sun K. “The effects of intravenous anesthetics on mouse embryonic fibroblast viability and proliferation” Springe Japan KK, 2012, 26(5):675-681

2011

Park JW, Choi J, Park Y, Sun K. “Haptic Virtual Fixture for Robotic Cardiac Catheter Navigation” Artificial Organs, 2011, 35(11):1127-1131

Song SJ, Choi J, Park YD, Hong S, Lee JJ, Ahn CB, Choi H, Sun K. “Sodium Alginate Hydrogel-Based Bioprinting Using a Novel Multinozzle Bioprinting System” Artificial Organs, 2011, 35(11):1132-1136

Kim JH, Jung Y, Kim SH, Sun K, Choi J, Kim HC, Park Y, Kim SH. “The enhancement of mature vessel formation and cardiac function in infarcted hearts using dual growth factor delivery with self-assembling peptides” Biomaterial, 2011, 32(26):6080-6088

Jeong GS, Kwon GH, Kang AR, Jung BY, Park Y, Chung S, Lee SH. “Microfluidic assay of endothelial cell migration in 3D interpenetrating polymer semi-network HA-Collagen hydrogel” Biomedical Microdevices, 2011, 13(4):717-723

Choi H, Lee HM, Nam KW, Choi J, Lee JJ, Kim HC, Song SJ, Ahn CB, Son HS, Lim CH, Son KH, Park YD, Jeong GS, Sun K. “A Durability Study of a Paracorporeal Pulsatile Electro-Mechanical   Pneumatic Biventricular Assist Device” Artificial Organs, 2011, 35(6):614-624

Jo S, Kim D, Woo J, Yoon G, Park YD, Tae G, Noh I “Development and physicochemical Evaluation of Chondroitin Sulfate-Poly(ethylene oside) Hydrogel” Macromolecular Research, 2011, 19(2); 147-155

Patents

– 심근경색 재생을 위한 세크레토뉴린 펩타이드가 고정된 하이드로젤 및 그 제조방법 1016148020000 대한민국 등록 2016.04.18

– 태반유래세포에 조건화된 배양 배지, 및 이를 이용한 무동물 및 무지지세포 줄기세포 배양 방법(10-1395214)   대한민국 등록 2014 05 08
– PLACENTA-DERIVED CELL-CONDITIONED CULTURE MEDIA AND ANIMAL-FREE, FEEDER-FREE METHOD FOR CULTURING STEM CELLS USING THE SAME US 13/421,544 미국(USA) 출원 2012 03 15
– 인간 태반 유래 지지 세포를 이용한 생쥐 배아줄기세포의 배양 방법 및 그 배양 배지 10-1133298 대한민국 등록 2012 03 30인간 태반 유래 지지 세포를 이용한 인간 배아줄기세포의 배양 방법 및 그 배양 배지 10-1133324 대한민국 등록 2012 03 30
– 인간 태반 중간엽줄기세포를 이용한 인간 골수 및 제대혈 단핵세포로부터 CD34+ 조혈모세포 또는 CD14+ 단핵구로의 분화배양 방법 10-0981093 대한민국 등록 2009 05 09
– 텔로머라제억제 siRNA 발현벡터 및 이를 이용한 유전자치료제 10-0635453 대한민국 등록 2006 10 11
– 안티센스 텔로머라제를 생산하는 아데노바이러스 및 이를 이용한 배아줄기세포로부터 조혈모세포의 분화 유도 및 증식 방법 10-0635454 대한민국 등록 2006 10 11